Molecular Diversity of Organic Cation Transporter (OCT) Mediating Renal Excretion of Drugs.
نویسندگان
چکیده
منابع مشابه
Sex differences in the mRNA, protein, and functional expression of organic anion transporter (Oat) 1, Oat3, and organic cation transporter (Oct) 2 in rabbit renal proximal tubules.
Sex differences in transport of the organic anion (OA) substrate p-aminohippurate (PAH) and the organic cation (OC) substrate tetraethylammonium (TEA) have been recognized for some time. In the rat kidney, androgens up-regulate and estrogens down-regulate PAH and TEA transport, which correlate with similar changes in mRNA and protein expression for the renal basolateral membrane transporters or...
متن کاملTranscription factor organic cation transporter 1 (OCT-1) affects the expression of porcine Klotho (KL) gene
Klotho (KL), originally discovered as an aging suppressor, is a membrane protein that shares sequence similarity with the β-glucosidase enzymes. Recent reports showed Klotho might play a role in adipocyte maturation and systemic glucose metabolism. However, little is known about the transcription factors involved in regulating the expression of porcine KL gene. Deletion fragment analysis identi...
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BACKGROUND/AIM To elucidate the mechanism responsible for developing acute kidney injury in patients with diabetes mellitus, we also evaluated the issue of whether advanced glycation endproducts (AGEs) influence the expressions of multi antimicrobial extrusion protein (MATE1/SLC47A1) in tubular cells. MATERIALS AND METHODS To detect changing expression of MATE1/SLC47A1 in dose- and time-depen...
متن کاملSignificance of downregulation of renal organic cation transporter (SLC47A1) in cisplatin-induced proximal tubular injury [Corrigendum]
[This corrects the article on p. 1701 in vol. 8, PMID: 26203260.].
متن کاملThe tales of two organic cation transporters, OCT-1 and OCT-2, in Caenorhabditis elegans
Solute carrier transporters, previously thought to perform roles in the transport of ions and various nutrients are now assigned broader functions. These transporters have recently been shown to permit entry of therapeutic drugs into cells. There is growing interest to understand the broad spectrum of drugs and chemical compounds that are recognized by these transporters such that specific liga...
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ژورنال
عنوان ژورنال: YAKUGAKU ZASSHI
سال: 2002
ISSN: 0031-6903,1347-5231
DOI: 10.1248/yakushi.122.957